Quinidine, A Life-Saving Medication for Brugada Syndrome, Is Inaccessible in Many Countries
نویسندگان
چکیده
منابع مشابه
Quinidine, a life-saving medication for Brugada syndrome, is inaccessible in many countries.
OBJECTIVES The aim of this study was to determine the availability of quinidine throughout the world. BACKGROUND Quinidine is the only oral medication that is effective for preventing life-threatening ventricular arrhythmias due to Brugada syndrome and idiopathic ventricular fibrillation. However, because of its low price and restricted indication, this medication is not marketed in many coun...
متن کاملQuinidine for Brugada syndrome: Panacea or poison?
Brugada syndrome is associated with sudden cardiac death in young patients. Currently guidelines recommend the use of implantable cardioverter-defibrillator (ICD) in high-risk patients to prevent sudden cardiac death and adjunctive therapy with quinidine in those who have recurrent ventricular tachyarrhythmias to prevent electrical storm. Nevertheless, not all patients respond to quinidine, and...
متن کاملQuinidine in Brugada Syndrome: Still a Long Way to Go….
S ince Brugada syndrome was identified in 1992, its therapeutic management of patients has presented a great challenge for clinicians. In this issue of Circulation Arrhythmia and Electrophysiology, Belhassen et al 2 suggest both risk strati-fication of arrhythmia and therapeutic improvements using electrophysiological study (EPS) and quinidine. Although gradual progress in risk stratification a...
متن کاملEfficacy of quinidine in high-risk patients with Brugada syndrome.
BACKGROUND Automatic implantable cardioverter-defibrillator therapy is considered the only effective treatment for high-risk patients with Brugada syndrome. Quinidine depresses I(to) current, which may play an important role in the arrhythmogenesis of this disease. METHODS AND RESULTS The effects of quinidine bisulfate (mean dose, 1483+/-240 mg) on the prevention of inducible and spontaneous ...
متن کاملQuinidine induced electrocardiographic normalization in two patients with Brugada syndrome.
Two patients with Brugada syndrome are presented. The ECGs showed right precordial J waves and ST-segment elevation. Patient 1 was resuscitated from nocturnal ventricular fibrillation, patient 2 was asymptomatic. In only patient 1, flecainide was infused causing monomorphic "malignant" ventricular extrasystoles (R on T), demonstrating the deleterious effect of Class IC antiarrhythmic drugs in B...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2013
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2013.02.077